Decision-Making and Downstream Outcomes of the Gabapentinoid-Diuretic Prescribing Cascade
This cohort study found that among older veterans who received LD following gabapentinoid initiation and experienced a potential gabapentinoid-LD prescribing cascade, clinicians almost never explicitly considered gabapentinoid adverse drug effects in their treatment of edema. These findings suggest that potential downstream harms of this overlooked prescribing cascade are common, underscoring the importance of addressing prescribing cascades in clinical practice.
Authors
- Lisa McCarthy (ORCID: https://orcid.org/0000-0001-9087-1077)
- Matthew E. Growdon (ORCID: https://orcid.org/0000-0001-5997-4406)
- Bocheng Jing (ORCID: https://orcid.org/0000-0002-2021-5055)
- Michael A. Steinman (ORCID: https://orcid.org/0000-0002-9564-9480)
- W. James Deardorff (ORCID: https://orcid.org/0000-0002-7947-3008)
- Natalie Tjota
- P Gayda
- Kenneth S. Boockvar (ORCID: https://orcid.org/0000-0003-1165-5558)
- Rachel Campbell (ORCID: https://orcid.org/0009-0003-2219-9006)
Institutions
- San Francisco VA Medical Center (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Trillium Health Centre (CA)
- University of Alabama at Birmingham (US)
- Birmingham VA Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.45274
- Primary Topic
- Pharmaceutical Practices and Patient Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- University of California, San Francisco
- VA National Center for Patient Safety
- National Center for Advancing Translational Sciences