Effectiveness and Safety of High-Dose versus Standard-Dose Cefoperazone-Sulbactam in Severe Infections: A Multicenter Retrospective Study
High-dose cefoperazone-sulbactam showed superior clinical and microbiological efficacy compared to the standard dose without increased safety concerns. These findings support the use of high-dose regimens in critically ill patients or those with MDRO infections.
Authors
- Chi‐Kuei Hsu (ORCID: https://orcid.org/0000-0001-5702-7747)
- Chih‐Cheng Lai (ORCID: https://orcid.org/0000-0002-6334-2388)
- LI Cheng-han
- Yu‐Hsin Chiu (ORCID: https://orcid.org/0000-0002-4730-8104)
- Kuang‐Ming Liao (ORCID: https://orcid.org/0000-0003-4364-8248)
- Jin-Wei Liu (ORCID: https://orcid.org/0000-0002-2317-8157)
- Ping–Chin Chang
- Chien-Tung Chiu
- Yee-Huang Ku
- Hung-Jen Tang
Institutions
- Chi Mei Medical Center (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s551491
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35