IL-33/ST2 signaling promotes intrahepatic cholangiocarcinoma through reprogramming macrophage polarization via MAPK pathway
IL-33/ST2 signaling drives ICC progression by promoting M2 macrophage polarization via the MAPK pathway. Targeting this axis may represent a novel therapeutic strategy for ICC.
Authors
- Guohua Zuo
- Jun Feng (ORCID: https://orcid.org/0000-0002-1725-140X)
- Aimaiti Yasen (ORCID: https://orcid.org/0000-0002-0692-1594)
- Xiaomin Yang (ORCID: https://orcid.org/0000-0003-4923-517X)
- Guoying Wang (ORCID: https://orcid.org/0000-0002-0304-0986)
- Lu Zheng (ORCID: https://orcid.org/0000-0003-3277-250X)
- Yichen Tang (ORCID: https://orcid.org/0000-0002-1032-0636)
Institutions
- Army Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Xinqiao Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Experimental Cell Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.yexcr.2025.114845
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00