Public Awareness of Rabies and Post-Bite Practices in Makkah Region of Saudi Arabia: Cross-Sectional Study

<b>Background:</b> Rabies is a fatal yet preventable zoonosis. In Saudi Arabia, uneven surveillance and limited public awareness may delay post-exposure prophylaxis (PEP). In Makkah, where residents regularly encounter free-roaming dogs, knowledge gaps could elevate exposure risks. <b>Objectives:</b> This study aims to assess public knowledge, attitudes, and post-bite practices regarding rabies, including wound washing and access to PEP among adult residents of the Makkah Region, and to examine associations with pet dog ownership. <b>Methods:</b> A cross-sectional survey was conducted in the Makkah Region (March-June 2025). An online validated bilingual questionnaire targeted residents ≥ 18 years via social media. Descriptive statistics, chi-square tests, 95% confidence intervals, and binomial logistic regression were applied in IBM SPSS v26; <i>p</i> < 0.05 was significant. <b>Results:</b> Of 523 respondents, 91.8% lived in Makkah city, 52.8% were female, and the age distribution was 18-24 years (44.2%), 25-34 years (35.6%), 35-44 years (12.0%), and ≥45 years (8.2%). Pet dog ownership was rare (1.9%), yet 39.4% reported stray dogs in their communities. Overall, 60.6% knew what rabies is and 63.7% knew it is vaccine-preventable, but 52.2% wrongly believed that transmission occurs only via dog bites. Hospitals (79.7%) and health centers (79.2%) were the most cited vaccination sites; social media was the dominant information source (74.6%). No significant association was found between pet ownership and rabies awareness (all <i>p</i> > 0.05). In multivariable regression (n = 509), adequate rabies knowledge increased the odds of an appropriate intended response (AOR 1.85, 95% CI: 1.27-2.68). Participants aged 30-40 years and those >50 years had significantly lower odds (AOR 0.45, 95% CI: 0.24-0.85 and AOR 0.23, 95% CI: 0.09-0.56, respectively). <b>Conclusions:</b> Despite moderate awareness, critical misconceptions and inconsistent first aid intentions persist. Priority actions include clear, locally adapted education on immediate wound washing and prompt PEP, standardized bite management pathways across facilities, reliable access to vaccines and immunoglobulin, and targeted social media micro-campaigns. By identifying public misconceptions, knowledge gaps, and preferred communication channels, this study provides baseline evidence to guide community awareness programs, intersectoral collaboration, and One Health-based surveillance essential for Saudi Arabia's progress toward the global "Zero rabies by 2030" goal.