Characterization of a factor VIII/immunoglobulin heavy chain μ double-knockout mouse model of hemophilia A for long-term exposure to factor VIII proteins
The DKO mouse model can be used for long-term studies of FVIII products and other hemostatic proteins, enabling the evaluation of repeated-dose PK and prophylactic efficacy without interference from inhibitor formation.
Authors
- Helmut Paul (ORCID: https://orcid.org/0000-0003-3217-4454)
- Lara Monica (ORCID: https://orcid.org/0009-0004-2325-6540)
- Larisa Belyanskaya
- Sonja Werwitzke
- Patrick Schauerte
- Luísa Aires (ORCID: https://orcid.org/0000-0001-9717-4186)
- Jonas Füner (ORCID: https://orcid.org/0009-0007-4664-3713)
- D L Jespersen
- Silvio Wuschko
- Andreas Tiede (ORCID: https://orcid.org/0000-0002-3600-8536)
- Olga Oleshko (ORCID: https://orcid.org/0000-0002-8066-0599)
Institutions
- Medizinische Hochschule Hannover (DE)
- Octapharma (Switzerland) (CH)
- Gesellschaft für Klinische Forschung (DE)
- Octapharma (Austria) (AT)
- Taconic (United States) (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.rpth.2025.103277
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00