Renal Net Acid Excretion During Growth and eGFR, Creatinine Clearance, and Albuminuria in Young Adulthood

These exclusively biomarker-based findings strongly suggest that habitually increased NAE and corresponding low urinary pH values in the normal range in childhood and adolescence are already related to incipient signs of kidney function decline in adulthood. Hence, as an important kidney health prevention measure, habitual consumption of alkalizing fruit- and vegetable-rich diets with clear ammoniagenic and NAE-lowering efficiency should start early in childhood.