The right kind of rarefaction: Coronary microvascular remodeling in right ventricle failure

Capillary rarefaction is a measurable histopathologic feature in explanted RV tissue that correlates with functional indices of RV performance. Our proof-of-concept findings suggest CMD may contribute to RV systolic dysfunction independent of PH subtype.

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Publication Details

Journal
JHLT Open
Published
2025-12-02
DOI
https://doi.org/10.1016/j.jhlto.2025.100459
Primary Topic
Cardiac Imaging and Diagnostics
Type
article
Field-Weighted Citation Impact
0.00
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article

The right kind of rarefaction: Coronary microvascular remodeling in right ventricle failure

Andrew P. Stein, Katharine Clapham, Avital Schurr, M. Schwietert et al.
JHLT Open
Cardiac Imaging and Diagnostics
article

The right kind of rarefaction: Coronary microvascular remodeling in right ventricle failure

Andrew P. Stein, Katharine Clapham, Avital Schurr, M. Schwietert, Sheila Talbot, Leonid Mirson, Andrew J. Bryant, Kirk D. Jones, Ellen C. Keeley, Dolores Petty, Angela P. Presson, Andrew H. Baird, Alex M. Parker, Kimberly Dumoff, Jeremy A. Mazurek, Andrew James Murphy, Cyrus Vahdatpour, S. Hansen, John Ryan, Priti Lal, Zhining Ou, Steven M. Kawut, Dylan Miller
article en

Abstract

Capillary rarefaction is a measurable histopathologic feature in explanted RV tissue that correlates with functional indices of RV performance. Our proof-of-concept findings suggest CMD may contribute to RV systolic dysfunction independent of PH subtype.

JHLT OpenVol. 11
Brigham Young University (US), University of Alabama at Birmingham Hospital (US), Thomas Jefferson University (US), Baylor College of Medicine (US), University of Utah (US), Pennsylvania Hospital (US), University of Florida Health (US), University of Alabama at Birmingham (US), University of Florida (US), University of Pennsylvania (US)
Openalex Percentile: Top 47%
Cardiac Imaging and Diagnostics
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