Clinical Translation of Antibody Positron Emission Tomography for Cancer Imaging
Hepatocellular carcinoma (HCC) lacks precise and noninvasive diagnostic tools. To address this, a new positron emission tomography (PET) radiotracer, [68Ga]Ga-XH-06, was developed. It uses an antibody fragment to target glypican-3 (GPC3), a highly specific biomarker, successfully visualizing GPC3 expressions in patients with HCC, potentially meeting an important unmet need. See related article by Lin et al., p. 550.
Authors
- Youngho Seo (ORCID: https://orcid.org/0000-0001-5908-6636)
- Robert R. Flavell (ORCID: https://orcid.org/0000-0002-8694-1199)
Institutions
- Lawrence Berkeley National Laboratory (US)
- University of California, San Francisco (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- University of San Francisco (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3784
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00