Evaluation of the Effectiveness and Safety of New Wound Coatings Based on Cod Collagen for Fast Healing of Burn Surfaces

Wound coatings in the form of sponge plates were obtained based on hydrogels of cod collagen (CC) copolymers. The synthesis of CC copolymers with pectin was carried out in the presence of a triethylbor-hexamethylenediamine (TEB-HMDA) complex, which forms free radicals under reaction conditions, and with polyethylene glycol (PEG) during photocatalysis in the presence of RbTe_1.5W_0.5O₆ oxide under visible-light irradiation with a LED lamp. Evaluation of their effectiveness and safety for rapid healing of wounds and burn surfaces has been conducted on small animals (rats). It has shown significantly higher efficiency in comparison with commercial collagen sponges based on bovine collagen. Coatings based on cod collagen contributed to the normalization of microcirculation levels according to the results of laser Doppler flowmetry and a high rate of reduction in the area of the scalped burn wound according to planimetry. The morphological studies indicate complete epithelialization with the formation of scar tissue in all studied groups of animals. The dynamics of microcirculation parameters indicate the repair of thermal burns during local treatment with wound-healing coatings against the background of normalization of the functioning of the microcirculatory system. It is advisable to use new collagen-based polymer sponge plates to increase the effectiveness of wound treatment of various origins, shorten recovery time, and optimize the course of typical physiological reactions during the wound process in order to accelerate tissue regeneration, as well as reduce mortality.