Palladium-Catalyzed Intramolecular Hydroarylation of N-Alkynylindoles: Regioselective Synthesis of Indole-Annulated Sulfur/Phosphorus Heterocycles
As privileged structural motifs, the efficient synthesis of multifused N-heterocycles remains highly challenging. Here, we report a palladium-catalyzed intramolecular hydroarylation of N-alkynyl indoles bearing an electron-withdrawing group at the 2-position. This reaction proceeds in high yield (up to 95%) and excellent regioselectivity, producing six-membered, indole-annulated sulfur/phosphorus heterocycles. This method offers a robust and efficient protocol for constructing these valuable scaffolds.
Authors
- Boxin Zhang (ORCID: https://orcid.org/0009-0005-2836-2403)
- Zhijin Fan (ORCID: https://orcid.org/0000-0001-5565-0949)
- Shun-Han Yang (ORCID: https://orcid.org/0000-0002-6697-4946)
- Haitao Yu (ORCID: https://orcid.org/0000-0003-3116-0288)
- Yanmei Li (ORCID: https://orcid.org/0000-0003-1215-5010)
- Yunlong Zhao (ORCID: https://orcid.org/0000-0001-5469-5694)
- Xinlu Li (ORCID: https://orcid.org/0000-0002-0766-4788)
- Ye Wang (ORCID: https://orcid.org/0000-0003-0764-2279)
Institutions
- Laboratoire de Synthèse Organique (FR)
- Hebei Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c04356
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00