Silver-Mediated Electrosynthesis of Substituted Isoquinolines via Cyclization of 2-Ethynylbenzaldehydes
The electrosynthesis of substituted isoquinolines via silver-mediated intramolecular cyclization of 2-ethynylbenzaldehydes with ammonium acetate is presented. The reaction employs Ag-(+)|C(-) electrodes in a DMF/isopropanol mixture at 60 °C using LiClO<sub>4</sub> as the supporting electrolyte, affording isoquinoline derivatives in yields up to 76%. Control experiments and DFT calculations were conducted to support a plausible reaction mechanism.
Authors
- Kléber T. de Oliveira (ORCID: https://orcid.org/0000-0002-9131-4800)
- Guilherme M. Martins (ORCID: https://orcid.org/0000-0002-0493-1270)
- Pedro P. de Castro (ORCID: https://orcid.org/0000-0002-3018-3130)
- Samuel R. Mendes (ORCID: https://orcid.org/0000-0002-2388-3008)
- Fernando R. Xavier (ORCID: https://orcid.org/0000-0002-2056-4052)
- Keila Gabrielle Pati Gomes
- Eliakin Sato de Borba
- Daniel C. A. Amélio
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Universidade do Estado de Santa Catarina (BR)
- Universidade Federal de São Carlos (BR)
- Universidade Vale do Rio Doce (BR)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1021/acsomega.5c08865
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00