Single-Cell RNA Sequencing Reveals Microglial Heterogeneity and Functional States After Cerebral Ischemia-Reperfusion Injury
Our study demonstrates that cerebral ischemia induces transcriptionally and functionally distinct microglial subpopulations, characterized by metabolic reprogramming and proinflammatory activation. ATF3 serves as a central regulator linking CH25H-mediated metabolic changes to cytokine-driven neuroinflammation, highlighting potential therapeutic targets for modulating microglial responses and mitigating ischemia-induced brain injury.
Authors
- Ruohan Sun (ORCID: https://orcid.org/0000-0003-2687-776X)
- Shirong Wen
- Bo Pan (ORCID: https://orcid.org/0000-0002-0984-2058)
- Changda Qu
- Yushi Tang (ORCID: https://orcid.org/0009-0009-6301-688X)
- Yujun Pan (ORCID: https://orcid.org/0000-0002-3727-0114)
- Yewei Qu
- Qi Zhang (ORCID: https://orcid.org/0000-0002-1905-0468)
- Shanshan Shi
- Fangqin Li
- Yi Lian
Institutions
- Harbin Medical University (CN)
- Heilongjiang Provincial Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s539404
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37