Liposomal Bupivacaine, Plain Bupivacaine, and Saline for Transversus Abdominis Plane Blocks: The CLEVELAND Randomized Trial
Single-shot, four-quadrant TAP blocks performed with liposomal bupivacaine, plain bupivacaine, or normal saline before incision for various open and laparoscopic abdominal procedures resulted in similar postoperative opioid consumption and pain scores at 24, 48, and 72 h. Absence of early benefit suggests that routine preincision, single-shot TAP blocks in this mixed surgical population provide little analgesia.
Authors
- Michael Valente (ORCID: https://orcid.org/0000-0002-2692-6739)
- Alparslan Turan (ORCID: https://orcid.org/0000-0001-9862-9306)
- Nour El Hage Chehade
- Wael Ali Sakr Esa
- Elyad Ekrami (ORCID: https://orcid.org/0000-0003-2244-4326)
- Karan Shah (ORCID: https://orcid.org/0000-0002-9838-0894)
- Jack Brooker (ORCID: https://orcid.org/0000-0001-9767-6530)
- Büşra Tok Çekmecelioğlu (ORCID: https://orcid.org/0000-0002-4049-6392)
- Harsha Nair
- Michael J. Rosen (ORCID: https://orcid.org/0000-0002-5149-718X)
- Daniel I. Sessler
- Carolin Mueller
- Ahmad Al Jarkas
Institutions
- Northwestern University (US)
- Cleveland Clinic (US)
- Outcomes Research Consortium (US)
- University of Texas Health Science Center at Dallas (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/aln.0000000000005869
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00