β-glucan-loaded nano-niosomes ameliorate spatial and associative memory impairment in a D-galactose-induced aging rat model via modulation of microglial pyroptosis and autophagy

β-glucan-loaded nano-niosomes exert neuroprotective effects through the simultaneous modulation of autophagy dysfunction and microglial-mediated inflammation, highlighting its potential as a therapeutic agent for neurodegenerative conditions. However, translation to human clinical practice remains uncertain and should be addressed in future studies using human-relevant models and early-phase clinical trials.

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Publication Details

Journal
Biomedicine & Pharmacotherapy
Published
2025-12-01
DOI
https://doi.org/10.1016/j.biopha.2025.118834
Primary Topic
Antioxidants, Aging, Portulaca oleracea
Type
article
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article

β-glucan-loaded nano-niosomes ameliorate spatial and associative memory impairment in a D-galactose-induced aging rat model via modulation of microglial pyroptosis and autophagy

Soheila Adeli, Hamidreza Sahrayi, Fatemeh Rahmati‐Dehkordi, Elham Zahedi et al.
Biomedicine & Pharmacotherapy
Antioxidants, Aging, Portulaca oleracea
article

β-glucan-loaded nano-niosomes ameliorate spatial and associative memory impairment in a D-galactose-induced aging rat model via modulation of microglial pyroptosis and autophagy

Soheila Adeli, Hamidreza Sahrayi, Fatemeh Rahmati‐Dehkordi, Elham Zahedi, Seyed Morteza Karimian
article en

Abstract

β-glucan-loaded nano-niosomes exert neuroprotective effects through the simultaneous modulation of autophagy dysfunction and microglial-mediated inflammation, highlighting its potential as a therapeutic agent for neurodegenerative conditions. However, translation to human clinical practice remains uncertain and should be addressed in future studies using human-relevant models and early-phase clinical trials.

Biomedicine & PharmacotherapyVol. 193
Sharif University of Technology (IR), Tehran University of Medical Sciences (IR)
Openalex Percentile: Top 59%
Antioxidants, Aging, Portulaca oleracea
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