β-glucan-loaded nano-niosomes ameliorate spatial and associative memory impairment in a D-galactose-induced aging rat model via modulation of microglial pyroptosis and autophagy
β-glucan-loaded nano-niosomes exert neuroprotective effects through the simultaneous modulation of autophagy dysfunction and microglial-mediated inflammation, highlighting its potential as a therapeutic agent for neurodegenerative conditions. However, translation to human clinical practice remains uncertain and should be addressed in future studies using human-relevant models and early-phase clinical trials.
Authors
- Soheila Adeli
- Hamidreza Sahrayi (ORCID: https://orcid.org/0000-0001-6942-6104)
- Fatemeh Rahmati‐Dehkordi
- Elham Zahedi (ORCID: https://orcid.org/0009-0000-2465-1164)
- Seyed Morteza Karimian
Institutions
- Sharif University of Technology (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.biopha.2025.118834
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00