High-fructose diet induces depressive-like behaviors and short-term memory deficits through hippocampal neurogenesis impairment via neural stem cell dysfunction
This study elucidates the mechanistic link between HFrD-induced metabolic disruption and NSC dysfunction, providing novel insights into the pathogenesis of fructose-associated neuropsychiatric disorders.
Authors
- Qiaona Wang
- Yuefeng Hu
- Fan Li (ORCID: https://orcid.org/0000-0002-4232-2492)
- Ruoyu Mu (ORCID: https://orcid.org/0000-0002-6093-0176)
- Z Feng
- Feng Zhou (ORCID: https://orcid.org/0000-0002-4509-4026)
- Chuanfeng Tang (ORCID: https://orcid.org/0000-0001-9811-8450)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4524-1812)
- Pengfei Xie (ORCID: https://orcid.org/0000-0002-4143-0993)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Normal University (CN)
- Nanjing Xiaozhuang University (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12986-025-01043-7
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Nanjing University of Chinese Medicine
- Nanjing University