Development of a novel in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes
Our results demonstrated promising proof-of-principle data as an in vitro MN test and suggest that hiPSC-derived T lymphocytes have a potential to make a significant contribution to the improvement of in vitro genotoxicity studies.
Authors
- Ryoko Matsuyama
- Ryota Kobayashi (ORCID: https://orcid.org/0009-0002-4491-6056)
- Shuichi Kitayama
- Koichi Saito (ORCID: https://orcid.org/0000-0001-6497-5286)
- A Kumagai (ORCID: https://orcid.org/0000-0001-6366-0821)
- Shin Kaneko (ORCID: https://orcid.org/0000-0003-2291-4586)
- Yohei Kawai (ORCID: https://orcid.org/0000-0002-7030-1541)
- Katsunori Sasaki
Institutions
- Sumitomo Chemical (Japan) (JP)
- Kyoto University (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s41021-025-00345-9
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00