Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
Reductions in valine and isoleucine in cancer cells primarily account for the multifaceted anti-cancer pharmacological activities of LAT1 inhibition by nanvuranlat. This study establishes the molecular basis for LAT1-targeted therapy and highlights growth-promoting processes in cancer cells that can be exploited pharmacologically by modulating the availability of specific amino acids.
Authors
- Kou Nishikubo (ORCID: https://orcid.org/0000-0002-8314-0708)
- Ryuichi Ohgaki (ORCID: https://orcid.org/0000-0002-6894-7239)
- Hiroki Okanishi
- Minhui Xu (ORCID: https://orcid.org/0000-0001-6565-3174)
- Yoshikatsu Kanai (ORCID: https://orcid.org/0000-0001-8126-286X)
Institutions
- Fujita Health University (JP)
- Fujita Health University Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s40170-025-00415-0
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00