Lumican stimulates osteogenic differentiation in bone marrow-derived mesenchymal stem cells through glycolytic reprogramming to alleviate osteoporosis
Lumican promotes hBMSC osteogenic differentiation and ameliorates OP by enhancing glycolysis and histone lactylation, providing a potential therapeutic target.
Authors
- Congcong Zeng (ORCID: https://orcid.org/0000-0002-0066-2739)
- Zhitao Liu (ORCID: https://orcid.org/0000-0002-2150-5548)
- Wei Liu (ORCID: https://orcid.org/0000-0002-9302-8170)
- Lei Xiang (ORCID: https://orcid.org/0000-0001-5740-5736)
- Heqing Huang
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- University of South China (CN)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1080/03008207.2025.2596769
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00