Optimising oncologic outcomes in pT3 glottic cancers treated by transoral laser microsurgery: the impact of adjuvant treatment
This study suggests that adjuvant treatment with (C)RT has a positive impact on DFS for pT3 glottic SCC treated by CO<sub>2</sub> TOLMS. The similar OS, DSS, and TLFS observed in pT3 SCC treated by CO<sub>2</sub> TOLMS alone and a selected group of unfavourable lesions needing adjuvant (C)RT show that adding such a treatment on top of conservative surgery may ensure good oncologic outcomes even in a selected subgroup of more aggressive glottic pT3. Further prospective studies should be conducted to validate these findings and confirm the relevance of adjuvant treatment(s) in this setting.
Authors
- Claudio Sampieri (ORCID: https://orcid.org/0000-0002-7699-2291)
- Paolo Bosio
- Cesare Piazza (ORCID: https://orcid.org/0000-0002-2391-9357)
- Giorgio Peretti (ORCID: https://orcid.org/0000-0003-2362-8936)
- Gabriele Zigliani
- Isabel Vilaseca (ORCID: https://orcid.org/0000-0003-4399-5522)
- Filippo Marchi (ORCID: https://orcid.org/0000-0002-7997-964X)
- Laura Ruiz-Sevilla (ORCID: https://orcid.org/0000-0002-7170-2814)
- Aurora Pinacoli (ORCID: https://orcid.org/0009-0003-8846-0449)
- Francesca Del Bon
Institutions
- Azienda Ospedaliera Bolognini Seriate (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Hospital Clínic de Barcelona (ES)
- Ospedale Policlinico San Martino (IT)
- Hospital Universitari Joan XXIII de Tarragona (ES)
- University of Brescia (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Acta Otorhinolaryngologica Italica
- Published
- 2025-12-01
- DOI
- https://doi.org/10.14639/0392-100x-a1372
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85