Potential Mechanisms of Tetramethylpyrazine in the Treatment of Traumatic Brain Injury Based on Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and in vivo Experiments
This study demonstrates that TMP exerts therapeutic effects on TBI by targeting the IL-17 and relaxin signalling pathways, providing evidence for its potential as a clinical therapy.
Authors
- Linjun Tang (ORCID: https://orcid.org/0000-0001-5205-3743)
- Rong Xu (ORCID: https://orcid.org/0000-0003-2263-4285)
- Yong Wu (ORCID: https://orcid.org/0000-0002-3667-8716)
- Hongwei Cheng (ORCID: https://orcid.org/0000-0001-8239-3941)
Institutions
- Anhui Medical University (CN)
- Wuhu Fourth People Hospital (CN)
- Wuhu No 1 People's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ijgm.s553186
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39