Transcriptomic Profiles from Stereo-EEGs May Reflect the Local Brain Cell Microenvironment in Human Epilepsy
These findings extend the evidence that SEEG electrodes reflect the molecular microenvironments of brain activity in patients with epilepsy, both at sites of seizure onset and within the wider seizure network. The approach has potential applications in intraoperative surgical decision-making, as well as to identify molecular biomarkers or therapeutic targets for the drug-resistant epilepsies.
Authors
- David C. Henshall (ORCID: https://orcid.org/0000-0001-6237-9632)
- Albert Sanfeliu (ORCID: https://orcid.org/0000-0003-2327-0209)
- Kieron J. Sweeney (ORCID: https://orcid.org/0000-0002-2282-6554)
- Peter Widdess‐Walsh (ORCID: https://orcid.org/0000-0003-4217-2575)
- Anuj Kumar Dwivedi (ORCID: https://orcid.org/0000-0002-0900-8186)
- Vijay Tiwari (ORCID: https://orcid.org/0000-0003-0292-6635)
- Donncha F. O’Brien
- Arun Mahesh
- John G. Larkin (ORCID: https://orcid.org/0009-0006-6317-179X)
Institutions
- Queen's University Belfast (GB)
- Royal College of Surgeons in Ireland (IE)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Beaumont Hospital (IE)
- Queens University (BD)
- Food for Health Ireland (IE)
- Data Fusion International (Ireland) (IE)
- Danish Diabetes Academy (DK)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3390/biom15121684
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Queen's University Belfast
- Queen's University