Preliminary analysis of the conserved Plasmodium falciparum k13 gene in Arbaminch and Mirab Abaya, Ethiopia
This study found no evidence of P. falciparum k13 gene mutations in isolates from Arbaminch and Mirab Abaya, indicating a high level of genetic conservation. Although minor genetic divergence was observed, particularly among Arbaminch isolates, the overall population remained genetically homogeneous. These findings highlight the continued effectiveness of artemisinin-based combination therapy in the region and emphasize the need for ongoing molecular surveillance to monitor potential resistance emergence.
Authors
- Kefiyalew Jote (ORCID: https://orcid.org/0000-0001-6130-6263)
- Bayissa Chala (ORCID: https://orcid.org/0000-0001-6001-4496)
- Abnet Abebe (ORCID: https://orcid.org/0000-0002-8539-9131)
- Lemu Golassa (ORCID: https://orcid.org/0000-0002-1216-8711)
- Cheikh Cambel Dieng (ORCID: https://orcid.org/0000-0003-2808-0455)
- Yirgalem Gebrehiwot
- Eugenia Lo
- Canelle Kipayko
Institutions
- Ethiopian Public Health Institute (ET)
- Addis Ababa University (ET)
- Drexel University (US)
- Adama Science and Technology University (ET)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12936-025-05706-x
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00