Tumor microenvironment-responsive COF-based core–shell cascade nanoreactor with photocatalytic H <sub>2</sub> O <sub>2</sub> self-supply for improved treatment
A smart tumor-responsive core-shell nanoreactor (Cu@Hemin@COF@PDA) based on covalent organic frameworks (COFs) was designed. It enhances antitumor therapy through photocatalytic H<sub>2</sub>O<sub>2</sub> self-supply, glutathione (GSH) depletion <i>via</i> Cu<sup>2+</sup>/Cu<sup>+</sup> conversion, and integrated photothermal properties.
Authors
- Yu Tian (ORCID: https://orcid.org/0000-0001-8006-6939)
- Yu‐Bin Dong (ORCID: https://orcid.org/0000-0002-9698-8863)
- Y.S. Li
- Wen-Xiu Ren
- Qing-Yun Huang (ORCID: https://orcid.org/0000-0002-3381-7872)
- Qianqian Sun (ORCID: https://orcid.org/0000-0002-6204-168X)
- Jie Feng (ORCID: https://orcid.org/0000-0002-1827-5577)
- Lili Tong (ORCID: https://orcid.org/0000-0001-7593-3938)
Institutions
- Yantai University (CN)
- Shandong Normal University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1039/d5cc06338h
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00