Host Immunogenetics and Chronic HCV Infection Shape Atopic Risk in Pediatric Beta-Thalassemia: A Genotype–Phenotype Study
Chronic HCV infection may contribute to immune tolerance and reduced allergic expression in BT patients, potentially modulated by IL10 and TLR7 genotypes. Further studies with functional immune profiling and larger cohorts are required.
Authors
- Valerio Caruso (ORCID: https://orcid.org/0009-0002-1955-8074)
- Valeria Tallarico (ORCID: https://orcid.org/0009-0000-1575-1905)
- Laura Colavita (ORCID: https://orcid.org/0000-0003-0984-2290)
- Mariarosa Calafiore
- Roberto Chimenz (ORCID: https://orcid.org/0000-0001-9143-4637)
- Luciana Rigoli (ORCID: https://orcid.org/0000-0003-1774-8173)
- Caterina Cuppari (ORCID: https://orcid.org/0000-0002-2431-400X)
- Clelia Cusmano (ORCID: https://orcid.org/0009-0004-8720-5267)
- Angelo Mazza (ORCID: https://orcid.org/0000-0002-3976-5495)
- Alessio Mancuso
- Mimma Caloiero
Institutions
- University of Pisa (IT)
- University of Messina (IT)
- Polo d’Innovazione di Genomica (IT)
- Azienda Ospedaliera Universitaria Policlinico "G. Martino" (IT)
- Azienda Ospedaliera Pugliese Ciaccio (IT)
- BioAge (Italy) (IT)
Publication Details
- Journal
- Genes
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3390/genes16121440
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00