Genetic Variations in Vitamin D Metabolism Linking Epigenetic Regulation and Microbiota Interactions: From Phenotype to Genotype
Genetic variants and epigenetic modifications may disrupt vitamin D metabolism and alter gut microbiota diversity, contributing to the development of various diseases. Evaluating vitamin D deficiency together with its genetic, epigenetic, and microbiota determinants is essential for developing effective prevention and treatment strategies. These findings emphasize the necessity of personalized, nutrigenetic-based approaches to optimize vitamin D function and support overall health.
Authors
- Bilge Özlüer Başer (ORCID: https://orcid.org/0000-0002-2400-6584)
- Gülsen Meral (ORCID: https://orcid.org/0000-0002-0567-7702)
- Rüya Ateşli
- Muhammed Yunus
- Elif Sibel Aslan (ORCID: https://orcid.org/0000-0002-3081-9004)
- Süay Özmen (ORCID: https://orcid.org/0000-0002-2679-174X)
- Neval Burkay (ORCID: https://orcid.org/0000-0002-7098-5410)
- Esma Gökcen Alper Acar (ORCID: https://orcid.org/0000-0002-3291-155X)
- Ece Aydin
Institutions
- Medigene (Germany) (DE)
- Mimar Sinan Güzel Sanatlar Üniversitesi (TR)
- İstanbul Nişantaşı Üniversitesi (TR)
- Biruni University (TR)
- Medical Genetics Center (DE)
- Research Centre for Medical Genetics (RU)
- Kent Hastanesi (TR)
Publication Details
- Journal
- Cureus
- Published
- 2025-12-02
- DOI
- https://doi.org/10.7759/cureus.98298
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00