Stroma-driven horizontal transfer of TCA-related proteins mediates metabolic plasticity and imatinib resistance in chronic myeloid leukemia
This study describes a novel mechanism of direct bone marrow-mediated protection of leukemic cells from imatinib/TKI, related to transfer of metabolic proteins leading to higher activity of TCA cycle, metabolic plasticity and adaptation. Targeting the stroma-driven TCA cycle-related metabolism combined with imatinib presents a promising strategy to achieve therapeutic efficacy to overcome bone marrow microenvironment-mediated protection in CML.
Authors
- Magdalena Lebiedzińska (ORCID: https://orcid.org/0000-0002-2725-5551)
- Dominik Cysewski (ORCID: https://orcid.org/0000-0001-6206-0672)
- Krzysztof Zabłocki (ORCID: https://orcid.org/0000-0002-9987-1257)
- Dawid Stępnik (ORCID: https://orcid.org/0000-0003-1999-911X)
- Monika Kusio-Kobiałka (ORCID: https://orcid.org/0000-0003-1995-2506)
- Dorota Dymkowska (ORCID: https://orcid.org/0000-0003-4798-4062)
- Vira Chumak (ORCID: https://orcid.org/0000-0002-4369-5063)
- Piotr Chrościcki (ORCID: https://orcid.org/0000-0002-4291-3284)
- Alicja Krop
- Mariusz R. Wiȩckowski (ORCID: https://orcid.org/0000-0003-0789-4521)
- Nikodem Kasak
- Katarzyna Piwocka (ORCID: https://orcid.org/0000-0001-6676-5282)
- Laura Turos-Korgul (ORCID: https://orcid.org/0000-0002-1732-3397)
- Tomasz Stokłosa (ORCID: https://orcid.org/0000-0001-6918-5056)
- Agata Kominek (ORCID: https://orcid.org/0000-0003-1567-9442)
- Joanna Szczepanowska (ORCID: https://orcid.org/0000-0002-0434-1262)
Institutions
- Medical University of Białystok (PL)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Medical University of Warsaw (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12964-025-02564-7
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77