A novel role of secreted methionine adenosyltransferase α2 in colorectal liver metastases
CRC cells secrete both MATα2 within EVs and free MATα2-t. EV-MATα2 can be internalized and act as a transcription factor to lower hepatocytes' MAT1A, the major defense against CRLM, while promoting CRC oncogenicity. Freely released MATα2-t acts as a ligand in an autocrine fashion to activate FAK, which is essential for CRC survival. Taken together, secreted MATα2 plays an essential role in promoting CRLM.
Authors
- Shelly Chi-Loo Lu (ORCID: https://orcid.org/0000-0003-2128-5407)
- Edwin M. Posadas (ORCID: https://orcid.org/0000-0001-8649-1346)
- Neil A. Bhowmick (ORCID: https://orcid.org/0000-0001-8747-5989)
- Mouad Edderkaoui (ORCID: https://orcid.org/0000-0002-2549-8242)
- Manisha Dagar
- Maria Lauda Tomasi (ORCID: https://orcid.org/0000-0001-8156-9052)
- Andrea Floris (ORCID: https://orcid.org/0000-0002-2368-2505)
- Swati Chandla
- Heping Yang (ORCID: https://orcid.org/0000-0003-1030-6495)
- Stephen Pandol
- Alexandra Gangi
- Monica Justo
- Youngyi Lim (ORCID: https://orcid.org/0000-0002-5609-8356)
Institutions
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- Los Angeles LGBT Center (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s13046-025-03599-x
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00