Fucosyltransferase 8‐Derived Circular <scp>RNA</scp> Drives <scp>M2</scp> Polarization of Macrophages Through <scp>ENO1</scp> ‐ <scp>TNF</scp> Signaling Axis to Promote Lung Cancer Progression
Our findings highlight the critical role of circFUT8 in lung cancer progression through its regulation of M2 macrophage polarization via interaction with ENO1. The findings suggest that circFUT8 may serve as both a diagnostic marker and a promising therapeutic target in lung cancer management. This study first identified the regulating oncogenic role of circFUT8 in lung cancer progression and the microenvironment.
Authors
- Yinzhong Shen (ORCID: https://orcid.org/0000-0002-7604-5139)
- Yidan Shen (ORCID: https://orcid.org/0000-0001-9163-7530)
- Peng Zhang (ORCID: https://orcid.org/0009-0008-5116-5418)
- Lei Wang (ORCID: https://orcid.org/0000-0001-5668-4737)
- Feng Li (ORCID: https://orcid.org/0000-0002-3529-9626)
- Yang Ren (ORCID: https://orcid.org/0000-0001-5584-8963)
- Qingguo Wu (ORCID: https://orcid.org/0000-0001-7994-9830)
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
Publication Details
- Journal
- Thoracic Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/1759-7714.70194
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81