Efficient Pd/AntPhos-catalyzed α-arylation of benzyl aryl ketones with aryl thianthrenium salts
An efficient catalytic α-arylation of benzyl aryl ketones with aryl thianthrenium salts was developed using Pd/AntPhos as the catalyst. Various α-arylated benzyl phenyl ketones were produced with up to 98% yield. H<sub>2</sub>O was necessary to achieve the high yields. This methodology was successfully applied to the efficient synthesis of droloxifene, tamoxifen and their analogs.
Authors
- Rui Shi (ORCID: https://orcid.org/0000-0002-3120-0596)
- Guodu Liu (ORCID: https://orcid.org/0000-0002-1249-0313)
- Xiangdong Zhang (ORCID: https://orcid.org/0000-0001-5893-2888)
Institutions
- Mongolian Academy of Sciences (MN)
- Inner Mongolia University (CN)
- Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences (CN)
- Inner Mongolia University of Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1039/d5cc06260h
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00