Evaluation of the Antitumor Effect of High-Energy Protons, Helium Ions, and Carbon during Irradiation of Ehrlich Adenocarcinoma Ascites Cells Ex Vivo
The regularities of tumor induction and growth in mice were studied during a single ex vivo irradiation of Ehrlich adenocarcinoma ascites cells with a beam of protons, helium ions (<sup>4</sup>Не), and carbon ions (<sup>12</sup>С) at doses of 10, 20, and 30 Gy. It was shown that, when tumor cells were exposed to all types of radiation, a dose-dependent increase in the antitumor effect was observed in the latent period of tumor appearance, the frequency of their induction, and tumor growth inhibition. According to all indices, <sup>12</sup>C had the greatest antitumor effect, <sup>4</sup>He occupied an intermediate position, and protons caused the least effect.
Authors
- V.E. Balakin (ORCID: https://orcid.org/0000-0001-9315-0101)
- Е. Н. Смирнова (ORCID: https://orcid.org/0000-0002-2348-6870)
- Т. А. Belyakova (ORCID: https://orcid.org/0000-0001-9570-5465)
- Olga M. Rozanova (ORCID: https://orcid.org/0000-0002-8804-4176)
- N. S. Strelnikova (ORCID: https://orcid.org/0000-0001-9040-1518)
- А. В. Смирнов (ORCID: https://orcid.org/0000-0001-5361-8232)
Institutions
- P.N. Lebedev Physical Institute of the Russian Academy of Sciences (RU)
- Institute of Theoretical and Experimental Biophysics (RU)
Publication Details
- Journal
- Doklady Biochemistry and Biophysics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1134/s1607672925601209
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00