Unraveling Alternating Hemiplegia of Childhood: A Case Report with Genetic and Clinical Insights
AHC is frequently misdiagnosed due to its rarity and varied presentation. Diagnosis is clinical and supported by genetic testing. Mutations in ATP1A3 are common and often cluster at specific hotspots. Management includes symptomatic treatment and supportive care, with flunarizine offering some benefit. This case highlights the need for early recognition and genetic confirmation of AHC to initiate therapy and improve quality of life.
Authors
- Niladri Sekhar Bhunia (ORCID: https://orcid.org/0000-0003-4126-3707)
- Atanu Kumar Dutta (ORCID: https://orcid.org/0000-0002-8413-3454)
- Nihar Ranjan Mishra (ORCID: https://orcid.org/0000-0002-5280-4719)
- Rohit Bhowmick (ORCID: https://orcid.org/0000-0002-2589-4499)
- Aditi Das (ORCID: https://orcid.org/0000-0002-6731-6726)
- Satyajit Mahapatra (ORCID: https://orcid.org/0000-0002-5516-6978)
- Subhankar Sarkar (ORCID: https://orcid.org/0000-0002-1316-0666)
- Rimjhim Sonowal (ORCID: https://orcid.org/0000-0002-3115-4876)
- Nupur Bajpai (ORCID: https://orcid.org/0009-0009-9689-657X)
- Abhishek Singh (ORCID: https://orcid.org/0000-0002-4690-5118)
Institutions
- All India Institute of Medical Sciences (IN)
- University of Kalyani (IN)
Publication Details
- Journal
- Case Reports in Neurology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1159/000548497
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00