CCL19+ fibroblast–CCR7+ T-cell crosstalk coordinates immunofibrotic signalling networks in systemic sclerosis
CCL19+ fibroblasts, potentially induced by VEGFA, may remodel profibrotic immune niches by promoting the infiltration of CCR7+ T cells, driving the progression of fibrosis in SSc.
Authors
- Rong Mu (ORCID: https://orcid.org/0000-0002-9111-2643)
- John Varga (ORCID: https://orcid.org/0000-0001-8400-687X)
- Jinlin Wang (ORCID: https://orcid.org/0009-0008-1010-5195)
- Dan Xing (ORCID: https://orcid.org/0000-0001-6966-3134)
- Huji Xu (ORCID: https://orcid.org/0000-0002-8588-118X)
- Xiandun Yuan
- Zhaohua Li (ORCID: https://orcid.org/0000-0002-6169-7767)
- Dan Xu (ORCID: https://orcid.org/0000-0002-4645-2665)
- Xiaoyu Li (ORCID: https://orcid.org/0009-0006-9840-6704)
- Wei Guo (ORCID: https://orcid.org/0000-0002-1923-6975)
- Dan Fang (ORCID: https://orcid.org/0009-0004-5434-3997)
- Yuebo Jin (ORCID: https://orcid.org/0000-0003-3379-8998)
- Dong Chen (ORCID: https://orcid.org/0000-0002-6114-9752)
- Ting Li (ORCID: https://orcid.org/0000-0002-2027-9462)
- Xiaoying Zhang (ORCID: https://orcid.org/0000-0002-9541-7479)
- Zhilong Chen (ORCID: https://orcid.org/0000-0003-4759-3598)
- Jing Ge
- Zhixin Wang
Institutions
- Peking University (CN)
- University of Michigan (US)
- Westlake University (CN)
- Shanghai Changzheng Hospital (CN)
- Michigan Medicine (US)
- Peking University People's Hospital (CN)
- Peking University Third Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1093/bjd/ljaf444
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00