A retrospective evaluation of preemptive liver transplantation for bile duct dysplasia in primary sclerosing cholangitis: Balancing risks and benefits
Individuals with primary sclerosing cholangitis (PSC) are at increased risk of developing bile duct cancer. In precancerous stages (bile duct dysplasia), liver transplantation (LT) may prevent progression to advanced, incurable cancer. In our evaluation of 512 patients with PSC who underwent LT, we found that the low diagnostic accuracy and unpredictable detection of mild dysplasia support a cautious, individualized approach to LT in precancerous stages of PSC, while more advanced dysplasia remains a valid indication for LT.
Authors
- Christina Villard (ORCID: https://orcid.org/0000-0003-4696-0931)
- S. Breder
- Lars Aabakken (ORCID: https://orcid.org/0000-0002-3622-3826)
- Annika Bergquist (ORCID: https://orcid.org/0000-0002-3858-6241)
- Kristine Wiencke (ORCID: https://orcid.org/0000-0003-1411-2276)
- Trine Folseraas (ORCID: https://orcid.org/0000-0003-2011-1923)
- Espen Melum (ORCID: https://orcid.org/0000-0001-6903-6878)
- Jon Lømo
- Benny Wang
- Lise Katrine Engesæter
- Pål‐Dag Line (ORCID: https://orcid.org/0000-0002-5884-9336)
- Johannes R. Hov (ORCID: https://orcid.org/0000-0002-5900-8096)
- Emma Eide
- Krzyztof Grzyb
Institutions
- Oslo University Hospital (NO)
- Karolinska University Hospital (SE)
- University of Oslo (NO)
- Karolinska Institutet (SE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101598
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00