Novel causal associations between plasma metabolites and prostate cancer risk revealed by mendelian randomization
This study provides robust genetic evidence supporting a causal role of specific plasma metabolites in prostate cancer development. The incorporation of a male-exclusive metabolomic dataset (METSIM) strengthens the validity of our findings for this male-specific cancer. These metabolites represent promising candidates for further mechanistic investigation into prostate cancer etiology and potential translation into clinical biomarkers.
Authors
- Hanghang Chen
- Huiduo Zhao
- Bingxin Meng (ORCID: https://orcid.org/0000-0003-1927-5728)
- Qi Liu (ORCID: https://orcid.org/0000-0001-6974-4989)
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Metabolism Open
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1016/j.metop.2025.100421
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00