The Effect of Quintuply-Fortified Salt on the Gut Microbiome of Young Children 1–5 y of Age in Punjab, India; A Substudy of a Randomized, Community-Based Trial
After 12 mo, QFS resulted no major changes in abundance of key taxa and minimal, inconsistent shifts in certain diversity metrics and relative to the iodized salt control, suggesting no adverse effects on microbiome composition among young children in this setting. Additional studies in settings with improved iron status are needed.This trial was registered at clinicaltrials.gov as NCT05166980 and at Clinical Trials Registry-India as CTRI/2022/02/040333.
Authors
- Bidhi L Singh (ORCID: https://orcid.org/0000-0001-6598-9743)
- Nancy F. Krebs (ORCID: https://orcid.org/0000-0001-5652-7547)
- Yvonne E Goh
- Christine M. McDonald (ORCID: https://orcid.org/0000-0003-1231-9003)
- Lauren Thompson (ORCID: https://orcid.org/0009-0002-4325-2788)
- Charles D. Arnold (ORCID: https://orcid.org/0000-0001-6510-3172)
- Reena Das (ORCID: https://orcid.org/0000-0002-8938-5423)
- Julie M. Long (ORCID: https://orcid.org/0000-0001-8784-8554)
- Gurjinder Kaur Brar
- Angela M. Zivkovic (ORCID: https://orcid.org/0000-0002-2828-7862)
- Mona Duggal (ORCID: https://orcid.org/0000-0002-9404-2871)
- Manu Jamwal (ORCID: https://orcid.org/0000-0002-6860-3698)
- Jamie Westcott
Institutions
- University of California, San Francisco (US)
- International Zinc Association (BE)
- Post Graduate Institute of Medical Education and Research (IN)
- University of Colorado Anschutz Medical Campus (US)
- University of California, Davis (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107580
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Postgraduate Institute of Medical Education and Research, Chandigarh