A New t(8;9) Translocation Involving the JAK2 Gene in Acute Myeloid Leukemia: A Case Report
This is the first report that molecularly characterizes the <i>HMBOX1::JAK2</i> fusion in a de novo AML patient. The identification of this novel alteration adds to the growing and heterogeneous molecular landscape of AML and suggests a potential new avenue for targeted therapy.
Authors
- Oscar Borsani (ORCID: https://orcid.org/0000-0001-7805-7806)
- Luca Arcaini (ORCID: https://orcid.org/0000-0002-9504-991X)
- Daniela Pietra (ORCID: https://orcid.org/0000-0002-6575-8766)
- Marina Boni (ORCID: https://orcid.org/0000-0001-8710-7246)
- Silvia Catricalà (ORCID: https://orcid.org/0000-0001-8294-1768)
- Marianna Rossi (ORCID: https://orcid.org/0000-0003-1661-1511)
- Patrizia Zappasodi (ORCID: https://orcid.org/0000-0001-9853-0592)
- Rita Zappatore (ORCID: https://orcid.org/0000-0002-5467-3740)
- Irene Dambruoso (ORCID: https://orcid.org/0000-0002-0490-9831)
- Elisa Rumi
Institutions
- University of Pavia (IT)
- Policlinico San Matteo Fondazione (IT)
Publication Details
- Journal
- Case Reports in Oncology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1159/000546561
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00