Emicizumab, the factor VIII mimetic bispecific monoclonal antibody: effects on thrombin generation and thromboelastometry
TGA thrombin peak or ETP performed at low tissue factor and phospholipid concentrations should be used to evaluate emicizumab activity. Thromboelastometry clotting time is valuable when performed without exogenous triggers.
Authors
- Armando Tripodi (ORCID: https://orcid.org/0000-0003-1602-2776)
- Marigrazia Clerici (ORCID: https://orcid.org/0000-0002-0194-3962)
- Cristina Novembrino (ORCID: https://orcid.org/0000-0003-1450-9935)
- Sara Arcudi (ORCID: https://orcid.org/0000-0001-5743-9098)
- Flora Peyvandi (ORCID: https://orcid.org/0000-0001-7423-9864)
- Erica Scalambrino (ORCID: https://orcid.org/0000-0001-6286-6924)
- Roberta Gualtierotti (ORCID: https://orcid.org/0000-0001-6465-7624)
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.rpth.2025.103237
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Milano
- Dipartimenti di Eccellenza
- European Commission
- Ministero della Salute
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Third Health Programme