LOX From Salivary Adenoid Cystic Carcinoma-Associated Fibroblast Promotes Fibrosis in the Pulmonary Pre-metastatic Niche
Our findings indicate that soluble LOX secreted by CAFs promotes metastatic progression through the induction of pulmonary fibrosis. Targeting this LOX-mediated pathway may represent a promising therapeutic strategy for preventing lung metastasis in patients with SACC. Furthermore, given the complexity of metastasis, future studies should investigate how fibrosis influences key stages of metastatic colony formation, including the extravasation and dormancy of circulating tumour cells.
Authors
- Tingjiao Liu
- Dong‐Yan Jin (ORCID: https://orcid.org/0000-0002-2778-3530)
- Song Nguyen Tran Bao
- Shengqiao Sun
- Jinwen Zhou
- Bo Sun
- Jing Kong (ORCID: https://orcid.org/0000-0003-3450-5456)
- Kabulo Katsh Cedric
Institutions
- Dalian Medical University (CN)
- Shanghai Stomatological Hospital (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1016/j.identj.2025.109298
- Citations
- 1
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01