Promoting astrocyte-neuron triiodothyronine shuttling attenuates brain damage in neonatal hypoxic-ischemic encephalopathy
We defined a previously unrecognized neuroprotective astrocyte subpopulation and revealed temporal heterogeneity in astrocytic inflammatory responses in HIE. We also identified a T3-mediated astrocyte-neuron crosstalk mechanism that mitigated HIBD, highlighting a tractable therapeutic avenue.
Authors
- Zhenlang Lin (ORCID: https://orcid.org/0000-0001-6850-0018)
- Yilan Yang (ORCID: https://orcid.org/0000-0002-3338-7542)
- Xinyi Wang (ORCID: https://orcid.org/0000-0003-3087-2638)
- Xingyun Wang (ORCID: https://orcid.org/0000-0002-8707-172X)
- Guosheng Yu (ORCID: https://orcid.org/0009-0007-2552-3982)
- Wei Zhou (ORCID: https://orcid.org/0000-0002-4503-1893)
- Yani Feng
Institutions
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Tongren Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s12974-025-03641-x
- Citations
- 1
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.49