SPICEiST: subcellular RNA pattern enhances cell clustering of imaging-based spatial transcriptomics
These findings highlight the value of leveraging subcellular transcript patterns to overcome the inherent limitations of imaging-based ST, particularly for small gene panels, and may provide new insights into tumor heterogeneity.
Authors
- Dongjoo Lee (ORCID: https://orcid.org/0000-0001-9381-0376)
- Sungwoo Bae (ORCID: https://orcid.org/0000-0002-3484-3749)
- Hongyoon Choi (ORCID: https://orcid.org/0000-0002-8895-2449)
- Youngmo Seong
Institutions
- Seoul National University Hospital (KR)
- Seoil University (KR)
Publication Details
- Journal
- Genomics & Informatics
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s44342-025-00056-1
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Research Foundation
- National Research Foundation of Korea