Real-Time Prediction of Irreversible Lesion Size During Pulsed Field Ablation: Prospective Validation of a Novel Ablation Index Based on Contact Force and Number of Applications in a Swine Beating Heart Model
A novel PF-ablation index incorporating CF and the number of PFA pulses provides high accuracy in predicting lesion depth in real-time. Intracardiac electrogram attenuation, impedance decrease, and electrode temperature are poor predictors of PFA lesion size.
Authors
- Jennifer Maffre (ORCID: https://orcid.org/0000-0001-7582-8409)
- Masafumi Sugawara (ORCID: https://orcid.org/0009-0002-8142-8000)
- Shady Nakhla (ORCID: https://orcid.org/0000-0002-4495-3845)
- Michael R. Franz (ORCID: https://orcid.org/0009-0009-9644-2535)
- Walid I. Saliba (ORCID: https://orcid.org/0000-0003-3324-8611)
- Ayman A. Hussein (ORCID: https://orcid.org/0000-0002-8359-1525)
- Pasquale Santangeli (ORCID: https://orcid.org/0000-0002-0023-9666)
- Hiroshi Nakagawa (ORCID: https://orcid.org/0000-0001-9368-519X)
- Assaf Govari
- Salman Farshchi-Heydari (ORCID: https://orcid.org/0009-0003-5158-1482)
- Oussama M. Wazni (ORCID: https://orcid.org/0000-0001-7115-7716)
- Andres Altmann (ORCID: https://orcid.org/0000-0002-8763-9370)
- Warren M. Jackman (ORCID: https://orcid.org/0000-0002-0023-7054)
- Christopher Beeckler
- Patrick H. Lam (ORCID: https://orcid.org/0000-0001-6196-1794)
- Taylor Spangler (ORCID: https://orcid.org/0009-0009-9394-293X)
- Tushar Sharma (ORCID: https://orcid.org/0000-0001-5857-4996)
- Atsushi Ikeda (ORCID: https://orcid.org/0009-0006-7043-7795)
Institutions
- Nihon University (JP)
- Heart Rhythm Society (US)
- Johnson & Johnson (United States) (US)
- Georgetown University (US)
- Bay Institute (US)
- Georgetown University Medical Center (US)
- Anna Needs Neuroblastoma Answers (US)
- Johnson & Johnson (Israel) (IL)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1161/circep.125.013911
- Citations
- 1
- Primary Topic
- Cardiac Arrhythmias and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39