Metformin Protects Against Persistent Atrial Fibrillation in an Equine Model
Metformin treatment conferred protection against early AF stabilization and selectively attenuated right atrial substrate complexity in a translationally relevant preclinical model. These findings support metformin as a lead molecule for AF prevention, warranting further mechanistic and clinical studies.
Authors
- Vladimír Sobota (ORCID: https://orcid.org/0000-0003-2285-5619)
- Joakim Bastrup (ORCID: https://orcid.org/0000-0002-4292-5234)
- Colin C. Schwarzwald (ORCID: https://orcid.org/0000-0002-6095-5402)
- Rasmus Kjøbsted (ORCID: https://orcid.org/0000-0002-0628-4994)
- Rikke Buhl (ORCID: https://orcid.org/0000-0002-8201-0186)
- Romain Barrès (ORCID: https://orcid.org/0000-0002-0158-519X)
- Charlotte Hopster‐Iversen (ORCID: https://orcid.org/0000-0003-3606-2484)
- Stefan M. Sattler (ORCID: https://orcid.org/0000-0003-3558-8329)
- Sarah Dalgas Nissen (ORCID: https://orcid.org/0000-0001-8598-7147)
- Kate M. Herum (ORCID: https://orcid.org/0000-0001-6617-6613)
- Thomas Jespersen (ORCID: https://orcid.org/0000-0001-6575-360X)
- Jørgen F. P. Wojtaszewski (ORCID: https://orcid.org/0000-0001-8185-3408)
- Arnela Saljic (ORCID: https://orcid.org/0000-0001-8910-0902)
- Urmas Roostalu (ORCID: https://orcid.org/0000-0002-7849-2055)
- Steen Larsen (ORCID: https://orcid.org/0000-0002-5170-4337)
- Arne van Hunnik (ORCID: https://orcid.org/0000-0003-3089-540X)
- Simon Libak Haugaard (ORCID: https://orcid.org/0000-0003-1787-134X)
- Stanley Nattel (ORCID: https://orcid.org/0000-0002-5565-3311)
- Sofie Troest Kjeldsen (ORCID: https://orcid.org/0000-0001-9828-5494)
- Helena Carstensen (ORCID: https://orcid.org/0000-0001-8952-9637)
- Ali Altıntaş (ORCID: https://orcid.org/0000-0002-8932-0160)
- Jesper B. Birk (ORCID: https://orcid.org/0000-0001-9775-4789)
- Thomas A. Jepps (ORCID: https://orcid.org/0000-0002-9903-714X)
- Christian M. Hansen (ORCID: https://orcid.org/0009-0005-7609-3308)
- Mélodie J. Schneider (ORCID: https://orcid.org/0000-0001-8739-8223)
- Sheyla Barrado Ballestero
- Josefine Natalie Synnestvedt
Institutions
- University of Copenhagen (DK)
- Centre National de la Recherche Scientifique (FR)
- Medical University of Białystok (PL)
- Université de Bordeaux (FR)
- Novo Nordisk (Denmark) (DK)
- Montreal Heart Institute (CA)
- Novo Nordisk Foundation (DK)
- Frederiksberg Hospital (DK)
- Maastricht University (NL)
- Electrophysiology and Heart Modeling Institute (FR)
- Swiss Institute of Equine Medicine (CH)
- Center for Pediatric Endocrinology Zurich (CH)
- Bristol-Myers Squibb (India) (IN)
- Institut de Pharmacologie Moléculaire et Cellulaire (FR)
- West German Heart and Vascular Center Essen (DE)
- Institut de Mathématiques de Bordeaux (FR)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1161/circep.125.013850
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00