Metagenomic insights into microbial community alterations and co-occurrence networks in infective endocarditis
We detected bacterial taxa, including Cutibacterium and Streptococcus troglodytae. Although S. troglodytae is rarely associated with IE, and Cutibacterium comprises low-abundance bacteria not typically linked to this condition. These findings demonstrate the value of NGS in identifying pathogens that standard culture methods may overlook. As these results are based on computational analyses, further laboratory validation is required. Incorporating NGS into diagnostic protocols may enhance pathogen detection in culture-negative IE and support more targeted treatment and prevention strategies.
Authors
- Amirreza Abbasi
- Negar Sadat Soleimani Zakeri (ORCID: https://orcid.org/0000-0002-3343-9904)
- Mohammad Ali Sheikh Beig Goharrizi (ORCID: https://orcid.org/0000-0001-7280-6175)
- Helia Jangi (ORCID: https://orcid.org/0009-0007-8782-6989)
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Tehran (IR)
- Yahoo (Spain) (ES)
- İstanbul Nişantaşı Üniversitesi (TR)
- Biotechnology Research Center (IR)
- Islamic Azad University Pharmaceutical Sciences Branch (IR)
- Piedmont University (US)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Genomics & Informatics
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s44342-025-00059-y
- Primary Topic
- Infective Endocarditis Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00