Dysregulated plasmacytoid dendritic cells in primary Sjögren's syndrome: normal functionality but decreased quantities
Our data enhances the understanding of pDC functionality in pSS and the mechanisms of their abnormal reduction in peripheral blood. We first report that excess IgG induced pDC apoptosis via FcRn and promoted the reduction of peripheral pDCs in patients with pSS.
Authors
- Lidan Zhao (ORCID: https://orcid.org/0000-0001-6599-3339)
- Yunyun Fei (ORCID: https://orcid.org/0000-0001-8743-7376)
- Jiaxin Zhou (ORCID: https://orcid.org/0000-0002-1664-3495)
- Xunyao Wu (ORCID: https://orcid.org/0000-0003-4852-0606)
- Mengtao Li (ORCID: https://orcid.org/0000-0003-4252-2889)
- Yu Peng (ORCID: https://orcid.org/0000-0001-6442-0803)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-4003-1771)
- Yan Zhao
- Yimeng Jia (ORCID: https://orcid.org/0009-0005-7111-3437)
- Mu Wang (ORCID: https://orcid.org/0000-0002-5351-7543)
- Chuiwen Deng (ORCID: https://orcid.org/0000-0001-9380-1736)
- Xiaofeng Zeng (ORCID: https://orcid.org/0000-0001-9484-8093)
- Rongli Li (ORCID: https://orcid.org/0000-0003-4048-5703)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.55563/clinexprheumatol/ric794
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China