Therapeutic Compliance Among Chronic HBV Carriers in Burkina Faso, 2021 - 2023

<i>Background:</i> Non-compliance with treatment is a major obstacle to reducing the morbidity and mortality of hepatitis B. According to the World Health Organization, solving the problem of non-compliance with treatment would represent significant progress. Burkina is a country with high endemicity and the factors associated with non-compliance with treatment remain poorly understood. <i>Objective:</i> This study aims to identify these factors and guide strategies. <i>Methodology:</i> This was a retrospective cohort study of 210 chronic carriers of hepatitis B from 2021-2023 in Burkina. The average scores for compliance with hygiene and dietary measures, compliance with medication intake and follow-up at the 6th; 12th, 18th, 24th month of our study were calculated. We speak of non-compliance with treatment if this average is < 75%. We conducted interviews with patients and performed a documentary review to collect data. The data were processed and analyzed by SAS 9.4® software. <i>Results:</i> The incidence of therapeutic non-compliance was 47.9%, including 60.9% among participants with a monthly income of less than 200,000 FCFA compared to 33.3% among those with an income greater than or equal to 200,000 FCFA. Adjusted for the values present, the factors associated with therapeutic non-compliance are monthly income <200,000 FCFA (p-value = 0.0066), inadequate knowledge of hepatitis B (p-value = 0.0440), age ≥ 50 years (p-value = 0.0191) and male gender (p-value = 0.0256). <i>Conclusion:</i> Hepatitis B treatment non-compliance remains a public health problem in Burkina. Factors associated with non-compliance include low income, inadequate knowledge of hepatitis B, age and gender. Addressing this requires making care more affordable, increasing awareness, diagnostic and management capacities.