Source of Information on Perceived Symptoms of STI and Challenges of Sexual and Reproductive Health (SRH) Among Adolescents in Rural Area, Oyo State Nigeria

<i>Background:</i> Adolescents in rural Nigeria often face limited access to accurate sexual and reproductive health (SRH) information and services due to cultural taboos, low parental involvement, and poor health infrastructure. Understanding sources of SRH information and the challenges faced is essential for designing effective interventions. <i>Method:</i> A mixed-method cross-sectional study was conducted among 240 adolescents aged 10–19 years in, Oyo State. Quantitative data were collected using structured, interviewer-administered questionnaires, while qualitative insights were gathered through 12 focus group discussions (FGDs). Data were analysed using SPSS Version 26 and thematic analysis for qualitative data. <i>Results:</i> Television, radio, and peers were the most common sources of SRH information (64.6%, 55.0%), while health workers (49.2%) and parents (40.0%) were less frequently reported. Over half of the respondents (55.0%) experienced high SRH-related challenges, such as lack of information, poor parental communication, and stigma. Adolescents aged 15–19 years (AOR=6.75, <i>p</i>=0.004) and those with tertiary education (AOR=35.24, <i>p</i><0.001) were more likely to access good SRH information. Higher education (AOR=0.12, <i>p</i>=0.004) and condom use (AOR=0.15, <i>p</i>=0.021) were significantly associated with reduced SRH challenges. FGDs reinforced these findings, citing communication barriers, cultural norms, and limited support systems. <i>Conclusion:</i> Adolescents in rural Oyo State depend heavily on informal channels for SRH information and face multiple access barriers. Strengthening school-based SRH education, improving parental communication, and scaling youth-friendly services are critical to addressing these gaps.