Extended verification of an automated MALDI-TOF mass spectrometry system for high throughput serum M-protein measurement
EXENT<sup>®</sup>-GAM enables sensitive and reproducible quantification and isotyping of M-proteins below the detection limit of SPEP and sIFE. Its ability to resolve analytical challenges posed by SPEP and sIFE represents a significant advancement. Further clinical studies are needed to confirm its potential in residual disease detection.
Authors
- E. Van Hecke (ORCID: https://orcid.org/0000-0001-9353-2038)
- Jan Van Droogenbroeck
- Michel R. Langlois (ORCID: https://orcid.org/0000-0002-3366-5047)
- Louis Nevejan (ORCID: https://orcid.org/0000-0001-8306-4023)
- Martine Vercammen (ORCID: https://orcid.org/0000-0003-4190-5562)
- Xavier Bossuyt (ORCID: https://orcid.org/0000-0001-6856-8485)
- Alexander Schauwvlieghe (ORCID: https://orcid.org/0000-0002-3224-3969)
Institutions
- Vrije Universiteit Brussel (BE)
- Rega Institute for Medical Research (BE)
- AZ Sint-Jan (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1515/cclm-2025-0894
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00