Development of a Rifapentine-Loaded Alendronate-Conjugated PLGA-PEG Nanosystem: A Novel Bone-Targeted Strategy for Osteoarticular Tuberculosis Treatment with Enhanced Drug Delivery and Bone Regeneration
The RPT/ALN-PLGA-PEG nanosystems demonstrated remarkable bone-targeting capability, sustained and potent antibacterial efficacy, and mitigation of bone destruction, coupled with the promotion of bone repair. These findings provide an innovative approach for addressing osteoarticular TB.
Authors
- Wei Hong (ORCID: https://orcid.org/0000-0001-5591-8028)
- Bo Zhao (ORCID: https://orcid.org/0000-0003-4458-2703)
- Zhen Wang (ORCID: https://orcid.org/0000-0003-3173-6961)
- Xiaopeng Qiu (ORCID: https://orcid.org/0009-0005-3990-1038)
- Ziquan Yang (ORCID: https://orcid.org/0000-0002-1862-3922)
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Shanxi Normal University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ijn.s478893
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00