StarTRAC-CYP2D6: a method for CYP2D6 allele-specific copy number determination using digital PCR
StarTRAC-<i>CYP2D6</i> is an effective, stand-alone method for determining the CN of specific star alleles. DNA quantity and possible interfering variants should be considered when optimizing workflows and accurately interpreting results. Protocols are currently being developed for higher-plex CN testing and discrimination.
Authors
- Andrea Gaedigk (ORCID: https://orcid.org/0000-0001-6968-1893)
- David Joun
- Erin C. Boone (ORCID: https://orcid.org/0000-0003-3044-5521)
- L S Lin (ORCID: https://orcid.org/0009-0005-4962-8370)
- Wendy Y. Wang (ORCID: https://orcid.org/0000-0002-0203-0196)
Institutions
- Thermo Fisher Scientific (United States) (US)
- Mercy Research (US)
- University of Missouri–Kansas City (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.3389/fphar.2025.1715830
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00