A convenient synthesis of enantioenriched α-haloaldehydes
We report a convenient synthesis of α-haloaldehydes involving oxidative cleavage of readily prepared, stable and storable halohydrins. This one-pot process affords α-haloaldehydes in high chemical purity and ee with minimal manipulation.
Authors
- Alan J. Brooke (ORCID: https://orcid.org/0000-0001-8261-0870)
- Robert Britton (ORCID: https://orcid.org/0000-0002-9335-0047)
- Mathew Sutherland
Institutions
- Simon Fraser University (CA)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1039/d5qo01415h
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Natural Sciences and Engineering Research Council of Canada